LOCUS pAd1128 25657 bp ds-DNA circular SYN 09-OCT-2019 DEFINITION pAd1128 is a 25,657 bp-long plasmid that contains the Ad5 E2 region and most of the late genes. It designed for constructing recombinant adenovirus vectors, in combination with the AdenoQuick2.0 plasmids (pAd1127, pAd1129, pAd1130, and their derivatives).pAd1128 includes among others the complete ORFs encoding IVa2, DNA polymerase, pre-terminal protein, pIIIa, penton, pV, pX, pVI, hexon, protease, DNA-binding protein, 100K, and pVIII. These adenovirus sequences are flanked by two SfiI sites, which generate non-symmetrical sticky ends suitable for directional cloning. ACCESSION . VERSION . KEYWORDS pAd1128 SOURCE synthetic DNA construct ORGANISM synthetic DNA construct REFERENCE 1 (bases 1 to 25657) AUTHORS OD260 Inc TITLE Direct Submission JOURNAL Exported Wednesday, Oct 9, 2019 from SnapGene 5.0.1 https://www.snapgene.com FEATURES Location/Qualifiers source 1..25657 /organism="synthetic DNA construct" /mol_type="other DNA" regulatory 15..20 /regulatory_class="polyA_signal_sequence" /note="E1B/pIX polyA signal" CDS complement(join(68..1404,1683..1695)) /codon_start=1 /gene="Ad5 E2B IVa2" /product="Ad5 E2B IVa2" /function="- Activates transcription from MLP and L4P ( Wright and Leppard (2013) J Virol 87:11617-25)" /label=Ad5 IVa2 /db_xref="GI:33465836" /protein_id="AAQ19289.1" /translation="METRGRRPAALQHQQDQPQAHPGQRAARSAPLHRDPDYADEDPAP VERHDPGPSGRAPTTAVQRKPPQPAKRGDMLDRDAVEQVTELWDRLELLGQTLKSMPTA DGLKPLKNFASLQELLSLGGERLLADLVRENMRVRDMLNEVAPLLRDDGSCSSLNYQLQ PVIGVIYGPTGCGKSQLLRNLLSSQLISPTPETVFFIAPQVDMIPPSELKAWEMQICEG NYAPGPDGTIIPQSGTLRPRFVKMAYDDLILEHNYDVSDPRNIFAQAAARGPIAIIMDE CMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDMAGNIANLKIQSK MHLISPRMHPSQLNRFVNTYTKGLPLAISLLLKDIFRHHAQRSCYDWIIYNTTPQHEAL QWCYLHPRDGLMPMYLNIQSHLYHVLEKIHRTLNDRDRWSRAYRARKTPK" CDS complement(join(1174..4767,10090..10098)) /codon_start=1 /product="Ad5 E2B DNA polymerase" /label=Ad5 DNA pol /db_xref="GI:33465837" /protein_id="AAQ19290.1" /translation="MALFQVQAHRARRLHAEAPDSGDQPPRRRVRQQPTRAAPAPARAR RRRAPAPSPGGSGAPPTSGGSPASPLLDASSKDTPAAHRPPRGTVVAPRGCGLLQAIDA ATNQPLEIRYHLDLARALTRLCEVNLQELPPDLTPRELQTMDSSHLRDVVIKLRPPRAD IWTLGSRGVVVRSTVTPLEQPDGQGQAAEVEDHQPNPPGEGLKFPLCFLVRGRQVNLVQ DVQPVHRCQYCARFYKSQHECSARRRDFYFHHINSHSSNWWREIQFFPIGSHPRTERLF VTYDVETYTWMGAFGKQLVPFMLVMKFGGDEPLVTAARDLAANLGWDRWEQDPLTFYCI TPEKMAIGRQFRTFRDHLQMLMARDLWSSFVASNPHLADWALSEHGLSSPEELTYEELK KLPSIKGIPRFLELYIVGHNINGFDEIVLAAQVINNRSEVPGPFRITRNFMPRAGKILF NDVTFALPNPRSKKRTDFLLWEQGGCDDTDFKYQYLKVMVRDTFALTHTSLRKAAQAYA LPVEKGCCAYQAVNQFYMLGSYRSEADGFPIQEYWKDREEFVLNRELWKKKGQDKYDII KETLDYCALDVQVTAELVNKLRDSYASFVRDAVGLTDASFNVFQRPTISSNSHAIFRQI VFRAEQPARSNLGPDLLAPSHELYDYVRASIRGGRCYPTYLGILREPLYVYDICGMYAS ALTHPMPWGPPLNPYERALAARAWQQALDLQGCKIDYFDARLLPGVFTVDADPPDETQL DPLPPFCSRKGGRLCWTNERLRGEVATSVDLVTLHNRGWRVHLVPDERTTVFPEWRCVA REYVQLNIAAKERADRDKNQTLRSIAKLLSNALYGSFATKLDNKKIVFSDQMDAATLKG ITAGQVNIKSSSFLETDNLSAEVMPAFQREYSPQQLALADSDAEESEDERAPTPFYSPP SGTPGHVAYTYKPITFLDAEEGDMCLHTLERVDPLVDNDRYPSHLASFVLAWTRAFVSE WSEFLYEEDRGTPLEDRPLKSVYGDTDSLFVTERGHRLMETRGKKRIKKHGGNLVFDPE RPELTWLVECETVCGACGADAYSPESVFLAPKLYALKSLHCPSCGASSKGKLRAKGHAA EGLDYDTMVKCYLADAQGEDRQRFSTSRTSLKRTLASAQPGAHPFTVTQTTLTRTLRPW KDMTLARLDEHRLLPYSESRPNPRNEEICWIEMP" CDS complement(join(4560..6566,10090..10098)) /codon_start=1 /product="Ad5 pTP" /label=Ad5 pTP /db_xref="GI:56160536" /protein_id="AP_000203.1" /translation="MALSVNDCARLTGQSVPTMEHFLPLRNIWNRVRDFPRASTTAAGI TWMSRYIYGYHRLMLEDLAPGAPATLRWPLYRQPPPHFLVGYQYLVRTCNDYVFDSRAY SRLRYTELSQPGHQTVNWSVMANCTYTINTGAYHRFVDMDDFQSTLTQVQQAILAERVV ADLALLQPMRGFGVTRMGGRGRHLRPNSAAAAAIDARDAGQEEGEEEVPVERLMQDYYK DLRRCQNEAWGMADRLRIQQAGPKDMVLLSTIRRLKTAYFNYIISSTSARNNPDRRPLP PATVLSLPCDCDWLDAFLERFSDPVDADSLRSLGGGVPTQQLLRCIVSAVSLPHGSPPP THNRDMTGGVFQLRPRENGRAVTETMRRRRGEMIERFVDRLPVRRRRRRVPPPPPPPEE EEGEALMEEEIEEEEEAPVAFEREVRDTVAELIRLLEEELTVSARNSQFFNFAVDFYEA MERLEALGDINESTLRRWVMYFFVAEHTATTLNYLFQRLRNYAVFARHVELNLAQVVMR ARDAEGGVVYSRVWNEGGLNAFSQLMARISNDLAATVERAGRGDLQEEEIEQFMAEIAY QDNSGDVQEILRQAAVNDTEIDSVELSFRFKLTGPVVFTQRRQIQEINRRVVAFASNLR AQHQLLPARGADVPLPPLPAGPEPPLPPGARPRHRF" misc_feature 6597..6753 /label=Ad5 VA-RNAI misc_feature 6655..6665 /label=VA-RNAI B box misc_feature 6853..7009 /label=Ad5 VA-RNAII CDS 7027..8274 /codon_start=1 /gene="L1" /product="Ad5 L1-52/55K " /label=Ad5 52/55K /db_xref="GI:33465839" /protein_id="AAQ19292.1" /translation="MHPVLRQMRPPPQQRQEQEQRQTCRAPSPPPTASGGATSAVDAAA DGDYEPPRRRARHYLDLEEGEGLARLGAPSPERHPRVQLKRDTREAYVPRQNLFRDREG EEPEEMRDRKFHAGRELRHGLNRERLLREEDFEPDARTGISPARAHVAAADLVTAYEQT VNQEINFQKSFNNHVRTLVAREEVAIGLMHLWDFVSALEQNPNSKPLMAQLFLIVQHSR DNEAFRDALLNIVEPEGRWLLDLINILQSIVVQERSLSLADKVAAINYSMLSLGKFYAR KIYHTPYVPIDKEVKIEGFYMRMALKVLTLSDDLGVYRNERIHKAVSVSRRRELSDREL MHSLQRALAGTGSGDREAESYFDAGADLRWAPSRRALEAAGAGPGLAVAPARAGNVGGV EEYDEDDEYEPEDGEY" CDS 8295..10051 /codon_start=1 /label=Ad5 pIIIa /db_xref="GI: 33465840 " /protein_id=" AAQ19293.1 " /translation="MMQDATDPAVRAALQSQPSGLNSTDDWRQVMDRIMSLTARNPDAF RQQPQANRLSAILEAVVPARANPTHEKVLAIVNALAENRAIRPDEAGLVYDALLQRVAR YNSGNVQTNLDRLVGDVREAVAQRERAQQQGNLGSMVALNAFLSTQPANVPRGQEDYTN FVSALRLMVTETPQSEVYQSGPDYFFQTSRQGLQTVNLSQAFKNLQGLWGVRAPTGDRA TVSSLLTPNSRLLLLLIAPFTDSGSVSRDTYLGHLLTLYREAIGQAHVDEHTFQEITSV SRALGQEDTGSLEATLNYLLTNRRQKIPSLHSLNSEEERILRYVQQSVSLNLMRDGVTP SVALDMTARNMEPGMYASNRPFINRLMDYLHRAAAVNPEYFTNAILNPHWLPPPGFYTG GFEVPEGNDGFLWDDIDDSVFSPQPQTLLELQQREQAEAALRKESFRRPSSLSDLGAAA PRSDASSPFPSLIGSLTSTRTTRPRLLGEEEYLNNSLLQPQREKNLPPAFPNNGIESLV DKMSRWKTYAQEHRDVPGPRPPTRRQRHDRQRGLVWEDDDSADDSSVLDLGGSGNPFAH LRPRLGRMF" CDS 10135..11850 /codon_start=1 /gene="L2" /product="Protein III, which forms a pentamer = penton base located at the vertices of the icosahedron." /label=Ad5 Penton base /translation="MRRAAMYEEGPPPSYESVVSAAPVAAALGSPFDAPLDPPFVPPRY LRPTGGRNSIRYSELAPLFDTTRVYLVDNKSTDVASLNYQNDHSNFLTTVIQNNDYSPG EASTQTINLDDRSHWGGDLKTILHTNMPNVNEFMFTNKFKARVMVSRLPTKDNQVELKY EWVEFTLPEGNYSETMTIDLMNNAIVEHYLKVGRQNGVLESDIGVKFDTRNFRLGFDPV TGLVMPGVYTNEAFHPDIILLPGCGVDFTHSRLSNLLGIRKRQPFQEGFRITYDDLEGG NIPALLDVDAYQASLKDDTEQGGGGAGGSNSSGSGAEENSNAAAAAMQPVEDMNDHAIR GDTFATRAEEKRAEAEAAAEAAAPAAQPEVEKPQKKPVIKPLTEDSKKRSYNLISNDST FTQYRSWYLAYNYGDPQTGIRSWTLLCTPDVTCGSEQVYWSLPDMMQDPVTFRSTRQIS NFPVVGAELLPVHSKSFYNDQAVYSQLIRQFTSLTHVFNRFPENQILARPPAPTITTVS ENVPALTDHGTLPLRNSIGGVQRVTITDARRRTCPYVYKALGIVSPRVLSSRTF" CDS 11857..12453 /codon_start=1 /product="core protein precursor pVII, which is cleaved by the virion-associated protease to generate polypeptide VII" /label=pVII /translation="MSILISPSNNTGWGLRFPSKMFGGAKKRSDQHPVRVRGHYRAPWG AHKRGRTGRTTVDDAIDAVVEEARNYTPTPPPVSTVDAAIQTVVRGARRYAKMKRRRRR VARRHRRRPGTAAQRAAAALLNRARRTGRRAAMRAARRLAAGIVTVPPRSRRRAAAAAA AAISAMTQGRRGNVYWVRDSVSGLRVPVRTRPPRN" CDS 12523..13629 /codon_start=1 /product="Ad5 pV" /label=Ad5 pV /db_xref="GI:56160541" /protein_id="AP_000208.1" /translation="MSKRKIKEEMLQVIAPEIYGPPKKEEQDYKPRKLKRVKKKKKDDD DELDDEVELLHATAPRRRVQWKGRRVKRVLRPGTTVVFTPGERSTRTYKRVYDEVYGDE DLLEQANERLGEFAYGKRHKDMLALPLDEGNPTPSLKPVTLQQVLPALAPSEEKRGLKR ESGDLAPTVQLMVPKRQRLEDVLEKMTVEPGLEPEVRVRPIKQVAPGLGVQTVDVQIPT TSSTSIATATEGMETQTSPVASAVADAAVQAVAAAASKTSTEVQTDPWMFRVSAPRRPR RSRKYGAASALLPEYALHPSIAPTPGYRGYTYRPRRRATTRRRTTTGTRRRRRRRQPVL APISVRRVAREGGRTLVLPTARYHPSIV" CDS 13657..13899 /codon_start=1 /product="Ad5 pX" /label=Ad5 pX /protein_id="AP_000209.1" /translation="MALTCRLRFPVPGFRGRMHRRRGMAGHGLTGGMRRAHHRRRRASH RRMRGGILPLLIPLIAAAIGAVPGIASVALQAQRH" CDS 13982..14734 /codon_start=1 /product="Ad5 pVI, precursor to polypeptide VI, a minor capsid cement protein present in 360 copies in the virion, organized in 60 hexamers.The precursor pVI contains 2 cleavage sites, one at residue 33 (MSGG/AFSW), and the other (IVGL/GVQS) 11 residues from the C-terminus (Weber,1995, Curr Top Microbiol Immunol. 199 ( Pt 1):227-35). " /function="- Polypeptide VI connects the bases of two adjacent peripentonal hexons and tethers the highly ordered capsid to the less ordered core region (San Martin and Burnett, 2003, Curr Top Microbiol Immunol. 272:57-94).- Polypeptide VI mediates membrane disruption following capsid disassembly (Wiethoff et al, 2005, J Virol 79:1992-2000) - The 11-residue peptide cleaved from the C-terminus by the adenovirus protease dimerizes by disulphide bond, and this dimer is necessary for the activation of the protease (Webster et al, 1993, Cell 72:97-104). " /label=Ad5 pVI /db_xref="GI:56160543" /protein_id="AP_000201.1" /translation="MEDINFASLAPRHGSRPFMGNWQDIGTSNMSGGAFSWGSLWSGIK NFGSTVKNYGSKAWNSSTGQMLRDKLKEQNFQQKVVDGLASGISGVVDLANQAVQNKIN SKLDPRPPVEEPPPAVETVSPEGRGEKRPRPDREETLVTQIDEPPSYEEALKQGLPTTR PIAPMATGVLGQHTPVTLDLPPPADTQQKPVLPGPTAVVVTRPSRASLRRAASGPRSLR PVASGNWQSTLNSIVGLGVQSLKRRRCF" CDS 14820..17678 /codon_start=1 /product="Ad5 Hexon" /label=Ad5 Hexon /db_xref="GI:56160544" /protein_id="AP_000211.1" /translation="MATPSMMPQWSYMHISGQDASEYLSPGLVQFARATETYFSLNNKF RNPTVAPTHDVTTDRSQRLTLRFIPVDREDTAYSYKARFTLAVGDNRVLDMASTYFDIR GVLDRGPTFKPYSGTAYNALAPKGAPNPCEWDEAATALEINLEEEDDDNEDEVDEQAEQ QKTHVFGQAPYSGINITKEGIQIGVEGQTPKYADKTFQPEPQIGESQWYETEINHAAGR VLKKTTPMKPCYGSYAKPTNENGGQGILVKQQNGKLESQVEMQFFSTTEAAAGNGDNLT PKVVLYSEDVDIETPDTHISYMPTIKEGNSRELMGQQSMPNRPNYIAFRDNFIGLMYYN STGNMGVLAGQASQLNAVVDLQDRNTELSYQLLLDSIGDRTRYFSMWNQAVDSYDPDVR IIENHGTEDELPNYCFPLGGVINTETLTKVKPKTGQENGWEKDATEFSDKNEIRVGNNF AMEINLNANLWRNFLYSNIALYLPDKLKYSPSNVKISDNPNTYDYMNKRVVAPGLVDCY INLGARWSLDYMDNVNPFNHHRNAGLRYRSMLLGNGRYVPFHIQVPQKFFAIKNLLLLP GSYTYEWNFRKDVNMVLQSSLGNDLRVDGASIKFDSICLYATFFPMAHNTASTLEAMLR NDTNDQSFNDYLSAANMLYPIPANATNVPISIPSRNWAAFRGWAFTRLKTKETPSLGSG YDPYYTYSGSIPYLDGTFYLNHTFKKVAITFDSSVSWPGNDRLLTPNEFEIKRSVDGEG YNVAQCNMTKDWFLVQMLANYNIGYQGFYIPESYKDRMYSFFRNFQPMSRQVVDDTKYK DYQQVGILHQHNNSGFVGYLAPTMREGQAYPANFPYPLIGKTAVDSITQKKFLCDRTLW RIPFSSNFMSMGALTDLGQNLLYANSAHALDMTFEVDPMDEPTLLYVLFEVFDVVRVHQ PHRGVIETVYLRTPFSAGNATT" CDS 17711..18325 /codon_start=1 /gene="Ad5 L3 23K" /product="Ad5 proteinase" /label=Ad5 proteinase /label=Ad5 protease /db_xref="GI:56160545" /protein_id="AP_000212.1" /translation="MGSSEQELKAIVKDLGCGPYFLGTYDKRFPGFVSPHKLACAIVNT AGRETGGVHWMAFAWNPHSKTCYLFEPFGFSDQRLKQVYQFEYESLLRRSAIASSPDRC ITLEKSTQSVQGPNSAACGLFCCMFLHAFANWPQTPMDHNPTMNLITGVPNSMLNSPQV QPTLRRNQEQLYSFLERHSPYFRSHSAQIRSATSFCHLKNM" CDS complement(18421..20010) /codon_start=1 /product="Ad5 DNA Binding Protein" /label=Ad5 DBP /translation="MASREEEQRETTPERGRGAARRPPTMEDVSSPSPSPPPPRAPPKK RMRRRIESEDEEDSSQDALVPRTPSPRPSTSAADLAIAPKKKKKRPSPKPERPPSPEVI VDSEEEREDVALQMVGFSNPPVLIKHGKGGKRTVRRLNEDDPVARGMRTQEEEEEPSEA ESEITVMNPLSVPIVSAWEKGMEAARALMDKYHVDNDLKANFKLLPDQVEALAAVCKTW LNEEHRGLQLTFTSNKTFVTMMGRFLQAYLQSFAEVTYKHHEPTGCALWLHRCAEIEGE LKCLHGSIMINKEHVIEMDVTSENGQRALKEQSSKAKIVKNRWGRNVVQISNTDARCCV HDAACPANQFSGKSCGMFFSEGAKAQVAFKQIKAFMQALYPNAQTGHGHLLMPLRCECN SKPGHAPFLGRQLPKLTPFALSNAEDLDADLISDKSVLASVHHPALIVFQCCNPVYRNS RAQGGGPNCDFKISAPDLLNALVMVRSLWSENFTELPRMVVPEFKWSTKHQYRNVSLPV AHSDARQNPFDF" CDS 20039..22462 /codon_start=1 /product="Ad5 L4-100K" /label=Ad5 100K /db_xref="GI:56160547" /protein_id="AP_000214.1" /translation="MESVEKKDSLTAPSEFATTASTDAANAPTTFPVEAPPLEEEEVII EQDPGFVSEDDEDRSVPTEDKKQDQDNAEANEEQVGRGDERHGDYLDVGDDVLLKHLQR QCAIICDALQERSDVPLAIADVSLAYERHLFSPRVPPKRQENGTCEPNPRLNFYPVFAV PEVLATYHIFFQNCKIPLSCRANRSRADKQLALRQGAVIPDIASLNEVPKIFEGLGRDE KRAANALQQENSENESHSGVLVELEGDNARLAVLKRSIEVTHFAYPALNLPPKVMSTVM SELIVRRAQPLERDANLQEQTEEGLPAVGDEQLARWLQTREPADLEERRKLMMAAVLVT VELECMQRFFADPEMQRKLEETLHYTFRQGYVRQACKISNVELCNLVSYLGILHENRLG QNVLHSTLKGEARRDYVRDCVYLFLCYTWQTAMGVWQQCLEECNLKELQKLLKQNLKDL WTAFNERSVAAHLADIIFPERLLKTLQQGLPDFTSQSMLQNFRNFILERSGILPATCCA LPSDFVPIKYRECPPPLWGHCYLLQLANYLAYHSDIMEDVSGDGLLECHCRCNLCTPHR SLVCNSQLLNESQIIGTFELQGPSPDEKSAAPGLKLTPGLWTSAYLRKFVPEDYHAHEI RFYEDQSRPPNAELTACVITQGHILGQLQAINKARQEFLLRKGRGVYLDPQSGEELNPI PPPPQPYQQQPRALASQDGTQKEAAAAAATHGRGGILGQSGRGGFGRGGGGHDGRLGEP RRGSFRGRRGVRRNTVTLGRIPLAGAPEIGNRFQHGYNLRSSGAAGTARSPTQP" CDS join(22173..22488,22691..23058) /codon_start=1 /product="Ad5 L4-33K" /label=Ad5 33K /db_xref="GI:56160548" /protein_id="AP_000215.1" /translation="MAPKKKLQLPPPPTDEEEYWDSQAEEVLDEEEEDMMEDWESLDEE ASEVEEVSDETPSPSVAFPSPAPQKSATGSSMATTSAPQAPPALPVRRPNRRWDTTGTR AAHTAPAAAAATAAATQKQRRPDSKTLTKPKKSTAAAAAGGGALRLAPNEPVSTRELRN RIFPTLYAIFQQSRGQEQELKIKNRSLRSLTRSCLYHKSEDQLRRTLEDAEALFSKYCA LTLKD" CDS 22173..22757 /codon_start=1 /product="Ad5 L4-22K" /label=Ad5 22K /db_xref="GI:56160549" /protein_id="AP_000216.1" /translation="MAPKKKLQLPPPPTDEEEYWDSQAEEVLDEEEEDMMEDWESLDEE ASEVEEVSDETPSPSVAFPSPAPQKSATGSSMATTSAPQAPPALPVRRPNRRWDTTGTR AGKSKQPPPLAQEQQQRQGYRSWRGHKNAIVACLQDCGGNISFARRFLLYHHGVAFPRN ILHYYRHLYSPYCTGGSGSNSSGHTEAKATG" CDS 23146..23829 /codon_start=1 /product="Ad5 pVIII (L4)" /function="Structural component of the virus capsid" /label=Ad5 pVIII /db_xref="GI:56160550" /protein_id="AP_000217.1" /translation="MSKEIPTPYMWSYQPQMGLAAGAAQDYSTRINYMSAGPHMISRVN GIRAHRNRILLEQAAITTTPRNNLNPRSWPAALVYQESPAPTTVVLPRDAQAEVQMTNS GAQLAGGFRHRVRSPGQGITHLTIRGRGIQLNDESVSSSLGLRPDGTFQIGGAGRSSFT PRQAILTLQTSSSEPRSGGIGTLQFIEEFVPSVYFNPFSGPPGHYPDQFIPNFDAVKDS ADGYD" rep_origin complement(23898..24486) /direction=LEFT /label=pUC19 Ori CDS complement(24657..25517) /codon_start=1 /gene="bla" /product="beta-lactamase" /label=AmpR /note="confers resistance to ampicillin, carbenicillin, and related antibiotics" /translation="MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYI ELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYS PVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRW EPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSA LPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGAS LIKHW" promoter complement(25518..25622) /gene="bla" /label=AmpR promoter ORIGIN 1 gagtggccaa cataaataaa aaaccagact ctgtttggat ttggatcaag caagtgtctt 61 gctgtcttta tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt 121 tgagggtcct gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca 181 tgggcataag cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg 241 tggtgttgta gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt 301 tcagtagcaa gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa 361 gctgggatgg gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg 421 ctatgttccc agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt 481 atccggtgca cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg 541 agacgccctt gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc 601 cacgggcggc ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca 661 ggatgagatc gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta 721 taatggttcc atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt 781 tgagttcaga tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg 841 taggggagat cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg 901 tgggcccgta aatcacacct attaccggct gcaactggta gttaagagag ctgcagctgc 961 cgtcatccct gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc 1021 tgaccaaatc cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa 1081 agtttttcaa cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca 1141 gttccaggcg gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc 1201 ctcgtttcgc gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg 1261 ggccagggtc atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt 1321 gaaggggtgc gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt 1381 gctgaagcgc tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc 1441 atagtccagc ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc 1501 gcacgagggg cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc 1561 cggggagtag gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt 1621 gagctctggc cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt 1681 acctctggtt tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc 1741 gtatacagac ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa 1801 ctcggaccac tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga 1861 ggggtagcgg tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc 1921 gccctcttcg gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt 1981 tcctgaaggg gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc 2041 gctgtctgcg agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc 2101 tgcgctaaga ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt 2161 gatgcctttg agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag 2221 cttggtggca aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt 2281 ttggtttttg tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg 2341 cgcaacgcac cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg 2401 ccaaccgcgg ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg 2461 ctcgttggtc cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag 2521 ctgcgtctcg tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc 2581 gaagtagtct atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag 2641 cgcgcgctcg tatgggttga gtgggggacc ccatggcatg gggtgggtga gcgcggaggc 2701 gtacatgccg caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg 2761 gtagcatctt ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc 2821 gaggaggtcg ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct 2881 gaagatggca tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc 2941 tgtgagacct accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag 3001 ctcggcggtg acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata 3061 cttatcctgt cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt 3121 ccagtactct tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa 3181 ctggttgacg gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc 3241 ggccttccgg agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta 3301 ctggtatttg aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg 3361 ctttttggaa cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc 3421 gcgaggcata aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat 3481 tacctgggcg gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag 3541 ttccaagaag cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag 3601 ctcttcaggg gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga 3661 agcgacgaat gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt 3721 cctaaactgg cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc 3781 ttgttcccag cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg 3841 ctcatctccg ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc 3901 catccaagta taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga 3961 gccgatcggg aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg 4021 aaagtagaag tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca 4081 gtactggcag cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac 4141 aaggaagcag agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac 4201 ttcggctgct tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac 4261 cacgccgcgc gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac 4321 atcgcgcaga tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag 4381 ctcctgcagg tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct 4441 aatttccagg ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg 4501 cgcgactacg gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc 4561 taaaagcggt gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga 4621 gggggcaggg gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg 4681 ctggcgaacg cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg 4741 acgggcccgg tgagcttgaa cctgaaagag agttcgacag aatcaatttc ggtgtcgttg 4801 acggcggcct ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg 4861 gccatgaact gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg 4921 gcggcgaggt cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg 4981 ttccagacgc ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc 5041 gcgagattga gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg 5101 tagttgaggg tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac 5161 gtggattcgt tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg 5221 gcgaagttga aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg 5281 atgagctcgg cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct 5341 tcttcaatct cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga 5401 ggggggacac ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc 5461 tccccgcggc gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt 5521 tggaagacgc cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg 5581 gatacggcgc taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac 5641 ctgagcgagt ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca 5701 cagtcgcaag gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt 5761 ctggcggagg tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc 5821 gacagaagca ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc 5881 caggcttcgt tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc 5941 ggcacttctt cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg 6001 gcggagtttg gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc 6061 atcggctgaa gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc 6121 tgcgtgaggg tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg 6181 atggtgtaag tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag 6241 agctcggtgt acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc 6301 cgcaccaggt actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag 6361 cgtagggtgg ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag 6421 atgtacctgg acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg 6481 acgcggttcc agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg 6541 gtcaggcgcg cgcaatcgtt gacgctctag accgtgcaaa aggagagcct gtaagcgggc 6601 actcttccgt ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg 6661 agccccgtat ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag 6721 gtgtgcgacg tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct 6781 gctgcgctag cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg 6841 aaagcattaa gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg 6901 ggacccccgg ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg 6961 tcatgcaaga ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt 7021 tcccagatgc atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa 7081 gagcagcggc agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca 7141 tccgcggttg acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac 7201 tacctggact tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg 7261 cacccaaggg tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg 7321 tttcgcgacc gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg 7381 cgcgagctgc ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc 7441 gacgcgcgaa ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc 7501 gcatacgagc agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg 7561 cgtacgcttg tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta 7621 agcgcgctgg agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg 7681 cagcacagca gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag 7741 ggccgctggc tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc 7801 ttgagcctgg ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt 7861 tacgcccgca agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag 7921 gggttctaca tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat 7981 cgcaacgagc gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc 8041 gagctgatgc acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc 8101 gagtcctact ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag 8161 gcagctgggg ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc 8221 gtggaggaat atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg 8281 atgtttctga tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga 8341 gccagccgtc cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt 8401 cgctgactgc gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg 8461 caattctgga agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga 8521 tcgtaaacgc gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg 8581 acgcgctgct tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc 8641 ggctggtggg ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca 8701 acctgggctc catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc 8761 ggggacagga ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac 8821 cgcaaagtga ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc 8881 tgcagaccgt aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg 8941 ctcccacagg cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc 9001 tgctgctaat agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc 9061 acttgctgac actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc 9121 aggagattac aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa 9181 ccctaaacta cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca 9241 gcgaggagga gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg 9301 acggggtaac gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt 9361 atgcctcaaa ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg 9421 tgaaccccga gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt 9481 tctacaccgg gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag 9541 acgacagcgt gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg 9601 cagaggcggc gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg 9661 ctgcggcccc gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca 9721 gcactcgcac cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc 9781 tgcagccgca gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc 9841 tagtggacaa gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc 9901 cgcgcccgcc cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg 9961 atgactcggc agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc 10021 accttcgccc caggctgggg agaatgtttt aaaaaaaaaa aaaagcatga tgcaaaataa 10081 aaaactcacc aaggccatgg caccgagcgt tggttttctt gtattcccct tagtatgcgg 10141 cgcgcggcga tgtatgagga aggtcctcct ccctcctacg agagtgtggt gagcgcggcg 10201 ccagtggcgg cggcgctggg ttctcccttc gatgctcccc tggacccgcc gtttgtgcct 10261 ccgcggtacc tgcggcctac cggggggaga aacagcatcc gttactctga gttggcaccc 10321 ctattcgaca ccacccgtgt gtacctggtg gacaacaagt caacggatgt ggcatccctg 10381 aactaccaga acgaccacag caactttctg accacggtca ttcaaaacaa tgactacagc 10441 ccgggggagg caagcacaca gaccatcaat cttgacgacc ggtcgcactg gggcggcgac 10501 ctgaaaacca tcctgcatac caacatgcca aatgtgaacg agttcatgtt taccaataag 10561 tttaaggcgc gggtgatggt gtcgcgcttg cctactaagg acaatcaggt ggagctgaaa 10621 tacgagtggg tggagttcac gctgcccgag ggcaactact ccgagaccat gaccatagac 10681 cttatgaaca acgcgatcgt ggagcactac ttgaaagtgg gcagacagaa cggggttctg 10741 gaaagcgaca tcggggtaaa gtttgacacc cgcaacttca gactggggtt tgaccccgtc 10801 actggtcttg tcatgcctgg ggtatataca aacgaagcct tccatccaga catcattttg 10861 ctgccaggat gcggggtgga cttcacccac agccgcctga gcaacttgtt gggcatccgc 10921 aagcggcaac ccttccagga gggctttagg atcacctacg atgatctgga gggtggtaac 10981 attcccgcac tgttggatgt ggacgcctac caggcgagct tgaaagatga caccgaacag 11041 ggcgggggtg gcgcaggcgg cagcaacagc agtggcagcg gcgcggaaga gaactccaac 11101 gcggcagccg cggcaatgca gccggtggag gacatgaacg atcatgccat tcgcggcgac 11161 acctttgcca cacgggctga ggagaagcgc gctgaggccg aagcagcggc cgaagctgcc 11221 gcccccgctg cgcaacccga ggtcgagaag cctcagaaga aaccggtgat caaacccctg 11281 acagaggaca gcaagaaacg cagttacaac ctaataagca atgacagcac cttcacccag 11341 taccgcagct ggtaccttgc atacaactac ggcgaccctc agaccggaat ccgctcatgg 11401 accctgcttt gcactcctga cgtaacctgc ggctcggagc aggtctactg gtcgttgcca 11461 gacatgatgc aagaccccgt gaccttccgc tccacgcgcc agatcagcaa ctttccggtg 11521 gtgggcgccg agctgttgcc cgtgcactcc aagagcttct acaacgacca ggccgtctac 11581 tcccaactca tccgccagtt tacctctctg acccacgtgt tcaatcgctt tcccgagaac 11641 cagattttgg cgcgcccgcc agcccccacc atcaccaccg tcagtgaaaa cgttcctgct 11701 ctcacagatc acgggacgct accgctgcgc aacagcatcg gaggagtcca gcgagtgacc 11761 attactgacg ccagacgccg cacctgcccc tacgtttaca aggccctggg catagtctcg 11821 ccgcgcgtcc tatcgagccg cactttttga gcaagcatgt ccatccttat atcgcccagc 11881 aataacacag gctggggcct gcgcttccca agcaagatgt ttggcggggc caagaagcgc 11941 tccgaccaac acccagtgcg cgtgcgcggg cactaccgcg cgccctgggg cgcgcacaaa 12001 cgcggccgca ctgggcgcac caccgtcgat gacgccatcg acgcggtggt ggaggaggcg 12061 cgcaactaca cgcccacgcc gccaccagtg tccacagtgg acgcggccat tcagaccgtg 12121 gtgcgcggag cccggcgcta tgctaaaatg aagagacggc ggaggcgcgt agcacgtcgc 12181 caccgccgcc gacccggcac tgccgcccaa cgcgcggcgg cggccctgct taaccgcgca 12241 cgtcgcaccg gccgacgggc ggccatgcga gcagctcgaa ggctggccgc gggtattgtc 12301 actgtgcccc ccaggtccag gcgacgagcg gccgccgcag cagccgcggc cattagtgct 12361 atgactcagg gtcgcagggg caacgtgtat tgggtgcgcg actcggttag cggcctgcgc 12421 gtgcccgtgc gcacccgccc cccgcgcaac tagattgcaa gaaaaaacta cttagactcg 12481 tactgttgta tgtatccagc ggcggcggcg cgcaacgaag ctatgtccaa gcgcaaaatc 12541 aaagaagaga tgctccaggt catcgcgccg gagatctatg gccccccgaa gaaggaagag 12601 caggattaca agccccgaaa gctaaagcgg gtcaaaaaga aaaagaaaga tgatgatgat 12661 gaacttgacg acgaggtgga actgctgcac gctaccgcgc ccaggcgacg ggtacagtgg 12721 aaaggtcgac gcgtaaaacg tgttttgcga cccggcacca ccgtagtctt tacgcccggt 12781 gagcgctcca cccgcaccta caagcgcgtg tatgatgagg tgtacggcga cgaggacctg 12841 cttgagcagg ccaacgagcg cctcggggag tttgcctacg gaaagcggca taaggacatg 12901 ctggcgttgc cgctggacga gggcaaccca acacctagcc taaagcccgt aacactgcag 12961 caggtgctgc ccgcgcttgc accgtccgaa gaaaagcgcg gcctaaagcg cgagtctggt 13021 gacttggcac ccaccgtgca gctgatggta cccaagcgcc agcgactgga agatgtcttg 13081 gaaaaaatga ccgtggaacc tgggctggag cccgaggtcc gcgtgcggcc aatcaagcag 13141 gtggcgccgg gactgggcgt gcagaccgtg gacgttcaga tacccactac cagtagcacc 13201 agtattgcca ccgccacaga gggcatggag acacaaacgt ccccggttgc ctcagcggtg 13261 gcggatgccg cggtgcaggc ggtcgctgcg gccgcgtcca agacctctac ggaggtgcaa 13321 acggacccgt ggatgtttcg cgtttcagcc ccccggcgcc cgcgccgttc gaggaagtac 13381 ggcgccgcca gcgcgctact gcccgaatat gccctacatc cttccattgc gcctaccccc 13441 ggctatcgtg gctacaccta ccgccccaga agacgagcaa ctacccgacg ccgaaccacc 13501 actggaaccc gccgccgccg tcgccgtcgc cagcccgtgc tggccccgat ttccgtgcgc 13561 agggtggctc gcgaaggagg caggaccctg gtgctgccaa cagcgcgcta ccaccccagc 13621 atcgtttaaa agccggtctt tgtggttctt gcagatatgg ccctcacctg ccgcctccgt 13681 ttcccggtgc cgggattccg aggaagaatg caccgtagga ggggcatggc cggccacggc 13741 ctgacgggcg gcatgcgtcg tgcgcaccac cggcggcggc gcgcgtcgca ccgtcgcatg 13801 cgcggcggta tcctgcccct ccttattcca ctgatcgccg cggcgattgg cgccgtgccc 13861 ggaattgcat ccgtggcctt gcaggcgcag agacactgat taaaaacaag ttgcatgtgg 13921 aaaaatcaaa ataaaaagtc tggactctca cgctcgcttg gtcctgtaac tattttgtag 13981 aatggaagac atcaactttg cgtctctggc cccgcgacac ggctcgcgcc cgttcatggg 14041 aaactggcaa gatatcggca ccagcaatat gagcggtggc gccttcagct ggggctcgct 14101 gtggagcggc attaaaaatt tcggttccac cgttaagaac tatggcagca aggcctggaa 14161 cagcagcaca ggccagatgc tgagggataa gttgaaagag caaaatttcc aacaaaaggt 14221 ggtagatggc ctggcctctg gcattagcgg ggtggtggac ctggccaacc aggcagtgca 14281 aaataagatt aacagtaagc ttgatccccg ccctcccgta gaggagcctc caccggccgt 14341 ggagacagtg tctccagagg ggcgtggcga aaagcgtccg cgccccgaca gggaagaaac 14401 tctggtgacg caaatagacg agcctccctc gtacgaggag gcactaaagc aaggcctgcc 14461 caccacccgt cccatcgcgc ccatggctac cggagtgctg ggccagcaca cacccgtaac 14521 gctggacctg cctccccccg ccgacaccca gcagaaacct gtgctgccag gcccgaccgc 14581 cgttgttgta acccgtccta gccgcgcgtc cctgcgccgc gccgccagcg gtccgcgatc 14641 gttgcggccc gtagccagtg gcaactggca aagcacactg aacagcatcg tgggtctggg 14701 ggtgcaatcc ctgaagcgcc gacgatgctt ctgatagcta acgtgtcgta tgtgtgtcat 14761 gtatgcgtcc atgtcgccgc cagaggagct gctgagccgc cgcgcgcccg ctttccaaga 14821 tggctacccc ttcgatgatg ccgcagtggt cttacatgca catctcgggc caggacgcct 14881 cggagtacct gagccccggg ctggtgcagt ttgcccgcgc caccgagacg tacttcagcc 14941 tgaataacaa gtttagaaac cccacggtgg cgcctacgca cgacgtgacc acagaccggt 15001 cccagcgttt gacgctgcgg ttcatccctg tggaccgtga ggatactgcg tactcgtaca 15061 aggcgcggtt caccctagct gtgggtgata accgtgtgct ggacatggct tccacgtact 15121 ttgacatccg cggcgtgctg gacaggggcc ctacttttaa gccctactct ggcactgcct 15181 acaacgccct ggctcccaag ggtgccccaa atccttgcga atgggatgaa gctgctactg 15241 ctcttgaaat aaacctagaa gaagaggacg atgacaacga agacgaagta gacgagcaag 15301 ctgagcagca aaaaactcac gtatttgggc aggcgcctta ttctggtata aatattacaa 15361 aggagggtat tcaaataggt gtcgaaggtc aaacacctaa atatgccgat aaaacatttc 15421 aacctgaacc tcaaatagga gaatctcagt ggtacgaaac agaaattaat catgcagctg 15481 ggagagtcct aaaaaagact accccaatga aaccatgtta cggttcatat gcaaaaccca 15541 caaatgaaaa tggagggcaa ggcattcttg taaagcaaca aaatggaaag ctagaaagtc 15601 aagtggaaat gcaatttttc tcaactactg aggcagccgc aggcaatggt gataacttga 15661 ctcctaaagt ggtattgtac agtgaagatg tagatataga aaccccagac actcatattt 15721 cttacatgcc cactattaag gaaggtaact cacgagaact aatgggccaa caatctatgc 15781 ccaacaggcc taattacatt gcttttaggg acaattttat tggtctaatg tattacaaca 15841 gcacgggtaa tatgggtgtt ctggcgggcc aagcatcgca gttgaatgct gttgtagatt 15901 tgcaagacag aaacacagag ctttcatacc agcttttgct tgattccatt ggtgatagaa 15961 ccaggtactt ttctatgtgg aatcaggctg ttgacagcta tgatccagat gttagaatta 16021 ttgaaaatca tggaactgaa gatgaacttc caaattactg ctttccactg ggaggtgtga 16081 ttaatacaga gactcttacc aaggtaaaac ctaaaacagg tcaggaaaat ggatgggaaa 16141 aagatgctac agaattttca gataaaaatg aaataagagt tggaaataat tttgccatgg 16201 aaatcaatct aaatgccaac ctgtggagaa atttcctgta ctccaacata gcgctgtatt 16261 tgcccgacaa gctaaagtac agtccttcca acgtaaaaat ttctgataac ccaaacacct 16321 acgactacat gaacaagcga gtggtggctc ccgggctagt ggactgctac attaaccttg 16381 gagcacgctg gtcccttgac tatatggaca acgtcaaccc atttaaccac caccgcaatg 16441 ctggcctgcg ctaccgctca atgttgctgg gcaatggtcg ctatgtgccc ttccacatcc 16501 aggtgcctca gaagttcttt gccattaaaa acctccttct cctgccgggc tcatacacct 16561 acgagtggaa cttcaggaag gatgttaaca tggttctgca gagctcccta ggaaatgacc 16621 taagggttga cggagccagc attaagtttg atagcatttg cctttacgcc accttcttcc 16681 ccatggccca caacaccgcc tccacgcttg aggccatgct tagaaacgac accaacgacc 16741 agtcctttaa cgactatctc tccgccgcca acatgctcta ccctataccc gccaacgcta 16801 ccaacgtgcc catatccatc ccctcccgca actgggcggc tttccgcggc tgggccttca 16861 cgcgccttaa gactaaggaa accccatcac tgggctcggg ctacgaccct tattacacct 16921 actctggctc tataccctac ctagatggaa ccttttacct caaccacacc tttaagaagg 16981 tggccattac ctttgactct tctgtcagct ggcctggcaa tgaccgcctg cttaccccca 17041 acgagtttga aattaagcgc tcagttgacg gggagggtta caacgttgcc cagtgtaaca 17101 tgaccaaaga ctggttcctg gtacaaatgc tagctaacta taacattggc taccagggct 17161 tctatatccc agagagctac aaggaccgca tgtactcctt ctttagaaac ttccagccca 17221 tgagccgtca ggtggtggat gatactaaat acaaggacta ccaacaggtg ggcatcctac 17281 accaacacaa caactctgga tttgttggct accttgcccc caccatgcgc gaaggacagg 17341 cctaccctgc taacttcccc tatccgctta taggcaagac cgcagttgac agcattaccc 17401 agaaaaagtt tctttgcgat cgcacccttt ggcgcatccc attctccagt aactttatgt 17461 ccatgggcgc actcacagac ctgggccaaa accttctcta cgccaactcc gcccacgcgc 17521 tagacatgac ttttgaggtg gatcccatgg acgagcccac ccttctttat gttttgtttg 17581 aagtctttga cgtggtccgt gtgcaccagc cgcaccgcgg cgtcatcgaa accgtgtacc 17641 tgcgcacgcc cttctcggcc ggcaacgcca caacataaag aagcaagcaa catcaacaac 17701 agctgccgcc atgggctcca gtgagcagga actgaaagcc attgtcaaag atcttggttg 17761 tgggccatat tttttgggca cctatgacaa gcgctttcca ggctttgttt ctccacacaa 17821 gctcgcctgc gccatagtca atacggccgg tcgcgagact gggggcgtac actggatggc 17881 ctttgcctgg aacccgcact caaaaacatg ctacctcttt gagccctttg gcttttctga 17941 ccagcgactc aagcaggttt accagtttga gtacgagtca ctcctgcgcc gtagcgccat 18001 tgcttcttcc cccgaccgct gtataacgct ggaaaagtcc acccaaagcg tacaggggcc 18061 caactcggcc gcctgtggac tattctgctg catgtttctc cacgcctttg ccaactggcc 18121 ccaaactccc atggatcaca accccaccat gaaccttatt accggggtac ccaactccat 18181 gctcaacagt ccccaggtac agcccaccct gcgtcgcaac caggaacagc tctacagctt 18241 cctggagcgc cactcgccct acttccgcag ccacagtgcg cagattagga gcgccacttc 18301 tttttgtcac ttgaaaaaca tgtaaaaata atgtactaga gacactttca ataaaggcaa 18361 atgcttttat ttgtacactc tcgggtgatt atttaccccc acccttgccg tctgcgccgt 18421 ttaaaaatca aaggggttct gccgcgcatc gctatgcgcc actggcaggg acacgttgcg 18481 atactggtgt ttagtgctcc acttaaactc aggcacaacc atccgcggca gctcggtgaa 18541 gttttcactc cacaggctgc gcaccatcac caacgcgttt agcaggtcgg gcgccgatat 18601 cttgaagtcg cagttggggc ctccgccctg cgcgcgcgag ttgcgataca cagggttgca 18661 gcactggaac actatcagcg ccgggtggtg cacgctggcc agcacgctct tgtcggagat 18721 cagatccgcg tccaggtcct ccgcgttgct cagggcgaac ggagtcaact ttggtagctg 18781 ccttcccaaa aagggcgcgt gcccaggctt tgagttgcac tcgcaccgta gtggcatcaa 18841 aaggtgaccg tgcccggtct gggcgttagg atacagcgcc tgcataaaag ccttgatctg 18901 cttaaaagcc acctgagcct ttgcgccttc agagaagaac atgccgcaag acttgccgga 18961 aaactgattg gccggacacg cggcgtcgtg cacgcagcac cttgcgtcgg tgttggagat 19021 ctgcaccaca tttcggcccc accggttctt cacgatcttg gccttgctag actgctcctt 19081 cagcgcgcgc tgcccgtttt cgctcgtcac atccatttca atcacgtgct ccttatttat 19141 cataatgctt ccgtgtagac acttaagctc gccttcgatc tcagcgcagc ggtgcagcca 19201 caacgcgcag cccgtgggct cgtgatgctt gtaggtcacc tctgcaaacg actgcaggta 19261 cgcctgcagg aatcgcccca tcatcgtcac aaaggtcttg ttgctggtga aggtcagctg 19321 caacccgcgg tgctcctcgt tcagccaggt cttgcatacg gccgccagag cttccacttg 19381 gtcaggcagt agtttgaagt tcgcctttag atcgttatcc acgtggtact tgtccatcag 19441 cgcgcgcgca gcctccatgc ccttctccca cgcagacacg atcggcacac tcagcgggtt 19501 catcaccgta atttcacttt ccgcttcgct gggctcttcc tcttcctctt gcgtccgcat 19561 accacgcgcc actgggtcgt cttcattcag ccgccgcact gtgcgcttac ctcctttgcc 19621 atgcttgatt agcaccggtg ggttgctgaa acccaccatt tgtagcgcca catcttctct 19681 ttcttcctcg ctgtccacga ttacctctgg tgatggcggg cgctcgggct tgggagaagg 19741 gcgcttcttt ttcttcttgg gcgcaatggc caaatccgcc gccgaggtcg atggccgcgg 19801 gctgggtgtg cgcggcacca gcgcgtcttg tgatgagtct tcctcgtcct cggactcgat 19861 acgccgcctc atccgctttt ttgggggcgc ccggggaggc ggcggcgacg gggacgggga 19921 cgacacgtcc tccatggttg ggggacgtcg cgccgcaccg cgtccgcgct cgggggtggt 19981 ttcgcgctgc tcctcttccc gactggccat ttccttctcc tataggcaga aaaagatcat 20041 ggagtcagtc gagaagaagg acagcctaac cgccccctct gagttcgcca ccaccgcctc 20101 caccgatgcc gccaacgcgc ctaccacctt ccccgtcgag gcacccccgc ttgaggagga 20161 ggaagtgatt atcgagcagg acccaggttt tgtaagcgaa gacgacgagg accgctcagt 20221 accaacagag gataaaaagc aagaccagga caacgcagag gcaaacgagg aacaagtcgg 20281 gcggggggac gaaaggcatg gcgactacct agatgtggga gacgacgtgc tgttgaagca 20341 tctgcagcgc cagtgcgcca ttatctgcga cgcgttgcaa gagcgcagcg atgtgcccct 20401 cgccatagcg gatgtcagcc ttgcctacga acgccaccta ttctcaccgc gcgtaccccc 20461 caaacgccaa gaaaacggca catgcgagcc caacccgcgc ctcaacttct accccgtatt 20521 tgccgtgcca gaggtgcttg ccacctatca catctttttc caaaactgca agatacccct 20581 atcctgccgt gccaaccgca gccgagcgga caagcagctg gccttgcggc agggcgctgt 20641 catacctgat atcgcctcgc tcaacgaagt gccaaaaatc tttgagggtc ttggacgcga 20701 cgagaagcgc gcggcaaacg ctctgcaaca ggaaaacagc gaaaatgaaa gtcactctgg 20761 agtgttggtg gaactcgagg gtgacaacgc gcgcctagcc gtactaaaac gcagcatcga 20821 ggtcacccac tttgcctacc cggcacttaa cctacccccc aaggtcatga gcacagtcat 20881 gagtgagctg atcgtgcgcc gtgcgcagcc cctggagagg gatgcaaatt tgcaagaaca 20941 aacagaggag ggcctacccg cagttggcga cgagcagcta gcgcgctggc ttcaaacgcg 21001 cgagcctgcc gacttggagg agcgacgcaa actaatgatg gccgcagtgc tcgttaccgt 21061 ggagcttgag tgcatgcagc ggttctttgc tgacccggag atgcagcgca agctagagga 21121 aacattgcac tacacctttc gacagggcta cgtacgccag gcctgcaaga tctccaacgt 21181 ggagctctgc aacctggtct cctaccttgg aattttgcac gaaaaccgcc ttgggcaaaa 21241 cgtgcttcat tccacgctca agggcgaggc gcgccgcgac tacgtccgcg actgcgttta 21301 cttatttcta tgctacacct ggcagacggc catgggcgtt tggcagcagt gcttggagga 21361 gtgcaacctc aaggagctgc agaaactgct aaagcaaaac ttgaaggacc tatggacggc 21421 cttcaacgag cgctccgtgg ccgcgcacct ggcggacatc attttccccg aacgcctgct 21481 taaaaccctg caacagggtc tgccagactt caccagtcaa agcatgttgc agaactttag 21541 gaactttatc ctagagcgct caggaatctt gcccgccacc tgctgtgcac ttcctagcga 21601 ctttgtgccc attaagtacc gcgaatgccc tccgccgctt tggggccact gctaccttct 21661 gcagctagcc aactaccttg cctaccactc tgacataatg gaagacgtga gcggtgacgg 21721 tctactggag tgtcactgtc gctgcaacct atgcaccccg caccgctccc tggtttgcaa 21781 ttcgcagctg cttaacgaaa gtcaaattat cggtaccttt gagctgcagg gtccctcgcc 21841 tgacgaaaag tccgcggctc cggggttgaa actcactccg gggctgtgga cgtcggctta 21901 ccttcgcaaa tttgtacctg aggactacca cgcccacgag attaggttct acgaagacca 21961 atcccgcccg cctaatgcgg agcttaccgc ctgcgtcatt acccagggcc acattcttgg 22021 ccaattgcaa gccatcaaca aagcccgcca agagtttctg ctacgaaagg gacggggggt 22081 ttacttggac ccccagtccg gcgaggagct caacccaatc cccccgccgc cgcagcccta 22141 tcagcagcag ccgcgggccc ttgcttccca ggatggcacc caaaaagaag ctgcagctgc 22201 cgccgccacc cacggacgag gaggaatact gggacagtca ggcagaggag gttttggacg 22261 aggaggagga ggacatgatg gaagactggg agagcctaga cgaggaagct tccgaggtcg 22321 aagaggtgtc agacgaaaca ccgtcaccct cggtcgcatt cccctcgccg gcgccccaga 22381 aatcggcaac cggttccagc atggctacaa cctccgctcc tcaggcgccg ccggcactgc 22441 ccgttcgccg acccaaccgt agatgggaca ccactggaac cagggccggt aagtccaagc 22501 agccgccgcc gttagcccaa gagcaacaac agcgccaagg ctaccgctca tggcgcgggc 22561 acaagaacgc catagttgct tgcttgcaag actgtggggg caacatctcc ttcgcccgcc 22621 gctttcttct ctaccatcac ggcgtggcct tcccccgtaa catcctgcat tactaccgtc 22681 atctctacag cccatactgc accggcggca gcggcagcaa cagcagcggc cacacagaag 22741 caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc ggcggcagca 22801 gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg cgagcttaga 22861 aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca agaacaagag 22921 ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc 22981 gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa atactgcgcg 23041 ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat 23101 ctccagcggc cacacccggc gccagcacct gttgtcagcg ccattatgag caaggaaatt 23161 cccacgccct acatgtggag ttaccagcca caaatgggac ttgcggctgg agctgcccaa 23221 gactactcaa cccgaataaa ctacatgagc gcgggacccc acatgatatc ccgggtcaac 23281 ggaatacgcg cccaccgaaa ccgaattctc ctggaacagg cggctattac caccacacct 23341 cgtaataacc ttaatccccg tagttggccc gctgccctgg tgtaccagga aagtcccgct 23401 cccaccactg tggtacttcc cagagacgcc caggccgaag ttcagatgac taactcaggg 23461 gcgcagcttg cgggcggctt tcgtcacagg gtgcggtcgc ccgggcaggg tataactcac 23521 ctgacaatca gagggcgagg tattcagctc aacgacgagt cggtgagctc ctcgcttggt 23581 ctccgtccgg acgggacatt tcagatcggc ggcgccggcc gctcttcatt cacgcctcgt 23641 caggcaatcc taactctgca gacctcgtcc tctgagccgc gctctggagg cattggaact 23701 ctgcaattta ttgaggagtt tgtgccatcg gtctacttta accccttctc gggacctccc 23761 ggccactatc cggatcaatt tattcctaac tttgacgcgg taaaggactc ggcggacggc 23821 tacgactgag gccaatgagg ccgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag 23881 gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga 23941 cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct 24001 ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc 24061 tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg 24121 gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc 24181 tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca 24241 ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag 24301 ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct 24361 ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc 24421 accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga 24481 tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca 24541 cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat 24601 taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac 24661 caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt 24721 gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt 24781 gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag 24841 ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct 24901 attaattgtt gccgggaagc tagagtaagc agttcgccag ttaatagttt gcgcaacgtt 24961 gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc 25021 tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt 25081 agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg 25141 gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg 25201 actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct 25261 tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc 25321 attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt 25381 tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt 25441 tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg 25501 aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat 25561 tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg 25621 cgcacatttc ccgaaaagtg ccacctgacg tcggcca //